Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease

Table 3 Performance analysis of different cutoff values of serum beta-glucan for patients with ulcerative colitis in relation to endoscopic and histological criteria

Predicted outcome		Cutoff	Sensitivity	Specificity	PPV	NPV	Accuracy
Endoscopic inflammation	Beta-glucan	40	40.0 (25.6-56.4)	87.5 (64.0-96.5)	87.5 (64.0-96.5)	40.0 (25.6-56.4)	54.9 (41.4-67.7)
	(μg/mL)	60	22.9 (12.1-39.0)	87.5 (64.0-96.5)	80.0 (49.0-94.3)	34.1 (21.6-49.4)	43.1 (30.5-56.7)
	Calprotectin	100	81.2 (57.0-93.4)	20.0 (3.6-62.4)	76.5 (52.7-90.4)	25.0 (4.6-69.9)	66.7 (45.4-82.8)
	(μg/g)	200	62.5 (38.6-81.5)	80.0 (37.5-96.4)	90.9 (62.3-98.4)	40.0 (16.8-68.7)	66.7 (45.4-82.8)
	CRP	3	60.9 (40.8-77.8)	20.0 (5.7-51.0)	63.7 (42.9-80.3)	18.2 (5.1-47.7)	48.5 (32.5-64.8)
	(mg/L)	5	43.5 (25.6-63.2)	60.0 (31.3-83.2)	71.4 (45.3-88.3)	31.6 (15.4-54.0)	48.5 (32.5-64.8)
Histological inflammation	Beta-glucan	40	66.7 (35.4-87.9)	90.0 (69.9-97.2)	75.0 (40.9-92.8)	85.7 (65.4-95.0)	82.8 (65.5-92.4)
	(μg/mL)	60	55.6 (26.7-81.1)	95.0 (76.4-99.1)	83.3 (43.6-97.0)	82.6 (62.9-93.0)	82.8 (65.5-92.4)
	Calprotectin	100	100.0 (64.6-100.0)	25.0 (7.1-59.1)	53.8 (29.1-76.8)	100.0 (34.2-100.0)	60.0 (35.7-80.2)
	(μg/g)	200	85.7 (48.7-97.4)	50.0 (21.5-78.5)	60.0 (31.3-83.2)	80.0 (37.5-96.4)	66.7 (41.7-84.8)
	CRP	3	57.1 (25.0-84.2)	33.3 (13.8-60.9)	33.3 (13.8-60.9)	57.1 (25.0-84.2)	42.1 (23.1-63.7)
	(mg/L)	5	42.9 (15.8-74.9)	58.3 (31.9-80.7)	37.5 (13.7-69.4)	63.6 (35.4-84.8)	52.6 (31.7-72.7)

Endoscopic criteria based on the Mayo endoscopic subscore; Histological criteria based on the Geboes score. Parentheses show lower-upper 95% confidence interval. CRP: C-reactive protein; PPV: Positive predictive value; NPV: Negative predictive value.