Serum 1,3-beta-D-glucan as a noninvasive test to predict histologic activity in patients with inflammatory bowel disease

Table 2 Performance analysis of different cutoff values of serum beta-glucan for patients with Crohn’s disease in relation to endoscopic and histological criteria

Predicted outcome		Cutoff	Sensitivity	Specificity	PPV	NPV	Accuracy
Endoscopic inflammation	Beta-glucan	40	50.0 (39.0-61.0)	71.8 (56.2-83.5)	77.5 (64.1-87.0)	42.4 (31.2-54.4)	57.4 (48.3-66.0)
	(μg/mL)	60	34.2 (24.5-45.4)	87.2 (73.3-94.4)	83.9 (67.4-92.9)	40.5 (30.6-51.2)	52.2 (43.1-61.1)
	Calprotectin	100	75.0 (56.6-87.3)	53.3 (30.1-75.2)	75.0 (56.6-87.3)	53.3 (30.1-75.2)	67.4 (52.5-79.5)
	(μg/g)	200	53.6 (35.8-70.5)	66.7 (41.7-84.8)	75.0 (53.1-88.8)	43.5 (25.6-63.2)	58.1 (43.3-71.6)
	CRP	3	49.2 (37.1-61.4)	50.0 (31.4-68.6)	71.4 (56.4-82.8)	27.9 (16.7-42.7)	49.4 (39.0-59.8)
	(mg/L)	5	34.4 (23.7-46.9)	66.7 (46.7-82.0)	72.4 (54.3-85.3)	28.6 (18.4-41.5)	43.5 (33.5-54.1)
Histological inflammation	Beta-glucan	40	78.8 (62.2-89.3)	60.5 (44.7-74.4)	63.4 (48.1-76.4)	76.7 (59.1-88.2)	69.0 (57.5-78.6)
	(μg/mL)	60	57.6 (40.8-72.8)	76.3 (60.8-87.0)	67.9 (49.3-82.1)	67.5 (52.5-79.5)	67.6 (56.1-77.3)
	Calprotectin	100	69.2 (42.4-87.3)	41.7 (19.3-68.0)	56.2 (33.2-76.9)	55.6 (26.7-81.1)	56.0 (37.1-73.3)
	(μg/g)	200	46.1 (23.2-70.9)	50.0 (25.4-74.6)	50.0 (25.4-74.6)	46.1 (23.2-70.9)	48.0 (30.0-66.5)
	CRP	3	57.7 (38.9-74.5)	62.1 (44.0-77.3)	57.7 (38.9-74.5)	62.1 (44.0-77.3)	60.0 (46.8-71.9)
	(mg/L)	5	53.8 (35.5-71.2)	79.3 (61.6-90.1)	70.0 (48.1-85.4)	65.7 (49.1-79.2)	67.3 (54.1-78.2)

Endoscopic criteria based on the Simple Endoscopic Score-Crohn’s disease endoscopic subscore; Histological criteria based on a modified Global Histologic disease activity score; Parentheses show lower-upper 95% confidence interval. CRP: C-reactive protein; PPV: Positive predictive value; NPV: Negative predictive value.