Fork head box M1 regulates vascular endothelial growth factor-A expression to promote the angiogenesis and tumor cell growth of gallbladder cancer

Figure 6 Fork head box M1 enhanced the angiogenesis of gallbladder cancer by regulating vascular endothelial growth factor-A in vivo. A: Tumor-bearing mice [(1) Lenti-fork head box M1 (FoxM1)-shRNA, (2) cDNA-FoxM1, (3) control: xenotransplantation model]; B: Tumor from the three groups; C: Body weight of tumor-bearing mice; D: Tumor volume of tumor-bearing mice; E: Hematoxylin-eosin staining of tumor foci; F: Hematoxylin-eosin staining of microvascular density; G: Immunohistochemistry staining of CD31. Five fields per sample were counted; four samples in the control and FoxM1 groups and three samples in the shFoxM1 group were analyzed. Scale bars: 200 μm. ^aP < 0.05, ^bP < 0.01. FoxM1: Fork head box M1.