Fork head box M1 regulates vascular endothelial growth factor-A expression to promote the angiogenesis and tumor cell growth of gallbladder cancer

Figure 5 Knockdown vascular endothelial growth factor-A in fork head box M1 overexpressed cells could partly reverse the malignant phenotype of gallbladder cancer cells. A: Relative protein expression of fork head box M1 and vascular endothelial growth factor-A; B and C: Clone formation of gallbladder cancer cells; D-G: Knockdown vascular endothelial growth factor-A in fork head box M1 overexpressed cells influenced migration and invasion abilities (cell invasion and migration assays, scale bars: 200 μm); H and I: Knockdown vascular endothelial growth factor-A in fork head box M1 overexpressed cells suppressed vessel generation ability (endothelial cell tube formation assay, scale bars: 100 μm). ^aP < 0.05, ^bP < 0.01. FoxM1: Fork head box M1; VEGF-A: Vascular endothelial growth factor-A.