Risk factors for lymph node metastasis in T1 esophageal squamous cell carcinoma: A systematic review and meta-analysis

doi:10.3748/wjg.v27.i8.737

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Feb 28, 2021 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Meta-Analysis

World J Gastroenterol. Feb 28, 2021; 27(8): 737-750
Published online Feb 28, 2021. doi: 10.3748/wjg.v27.i8.737

Table 2 Meta-analysis results for the relationship between lymph node metastasis and clinicopathological factors in T1 esophageal squamous cell carcinoma patients

Factors	Studies	Patients	Heterogeneity I² (P value)	Pooled OR (95%CI)	P value
Age (continuous) (yr)	6	1571	22% (0.27)	-0.81 (-1.75-0.14)	0.10
Sex (male/female)	12	2913	0% (0.78)	1.16 (0.91-1.48)	0.23
Tumor size (> 2/≤ 2) (cm)	6	1482	0% (0.74)	1.93 (1.49-2.50)	< 0.001^a
Tumor location (L/U-M)	10	2291	0% (0.57)	1.46 (1.17-1.82)	< 0.001^a
T1 substage (T1b/T1a)	15	3558	0% (0.87)	6.28 (4.93-8.00)	< 0.001^a
Differentiation (G3/G1-2)	11	1966	0% (0.49)	2.11 (1.64-2.72)	< 0.001^a
LVI (present/absent)	11	2226	40% (0.08)	5.86 (4.60-7.48)	< 0.001^a
Macroscopic type (nonflat/flat)	6	1213	35% (0.17)	3.17 (2.33-4.31)	< 0.001^a
INF (present/absent)	3	591	0% (0.66)	1.82 (0.89-3.73)	0.10

^aP < 0.05. CI: Confidence interval; ESCC: Esophageal squamous cell carcinoma; G1-2: Well differentiated-moderately differentiated; G3: Poorly differentiated; INF: Infiltrative growth pattern; L: Lower; LNM: Lymph node metastasis; LVI: Lymphovascular invasion; OR: Odds ratio; U-M: Upper-middle.

Citation: Jiang KY, Huang H, Chen WY, Yan HJ, Wei ZT, Wang XW, Li HX, Zheng XY, Tian D. Risk factors for lymph node metastasis in T1 esophageal squamous cell carcinoma: A systematic review and meta-analysis. World J Gastroenterol 2021; 27(8): 737-750
URL: https://www.wjgnet.com/1007-9327/full/v27/i8/737.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i8.737