Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

Figure 5 Sinapic acid downregulates nuclear factor kappa B in acute liver failure. A-H: Effect of sinapic acid on the protein expression of transforming growth factor-β1 (A), heme oxygenase-1 (B), nuclear factor erythroid 2-related factor 2 (C), nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha protein (D), nuclear factor kappa B (E), anti-apoptotic protein BCl2 (F), caspase 3 (G), and Bax in D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced acute liver failure (ALF) (H). The results are presented as the mean ± SE of six animals per group. ^aDenotes significant differences to the D-GalN/LPS-induced ALF group (P < 0.05); ^bdenotes significant differences compared to the normal control. TGF-β1: Transforming growth factor-β1; HO-1: Heme oxygenase-1; Nrf2: Nuclear factor erythroid 2-related factor 2; IkBα: Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha; NF-κb: Nuclear factor kappa B; SA: Sinapic acid; D-GalN/LPS: D-galactosamine/lipopolysaccharide.