Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice

Figure 4 Effects of atropine and tetrodotoxin on the enhancement of gastric antrum slow wave by Xiangbinfang granule. A and B: Representative trace of the effect of Xiangbinfang granule (XBF) 10^-1 g/L on slow waves of the gastric antrum pretreated with atropine 5 mmol/L in wild-type (WT) (A) and W/W^v mice (B); C-G: Histogram of atropine blocking the effect of XBF on the enhancement of resting membrane potential (C), frequency (D) and amplitude (E) of antral slow waves. Representative trace of the effect of 10^-1 g/L of XBF on slow waves of the gastric antrum pretreated with 10^-7 M of tetrodotoxin (TTX) in WT (F) and W/W^v (G) mice; H-J: Histogram of TTX blocking the effect of XBF on the enhancement of the resting membrane potential (H), frequency (I) and amplitude (J) of antral slow waves. (Compared with pretreatment, n = 3, ^aP < 0.05). WT: Wild-type; XBF: Xiangbinfang granule; TTX: Tetrodotoxin; CON: Basic control; ATR: Atropine.