Effect of liver inflammation on accuracy of FibroScan device in assessing liver fibrosis stage in patients with chronic hepatitis B virus infection

Table 3 Univariate and multivariate regression analyses of risk of misdiagnosis of fibrosis stage by transient elastography in all patients

Variables	Univariate analyses		Multivariate analyses
	OR (95%CI)	P value	OR (95%CI)	P value
Age (yr)	1.00 (0.99-1.03)	0.472
Male, n	0.65 (0.42-1.02)	0.059
BMI (kg/m2)	1.01 (0.93-1.09)	0.832
TBIL > 2 ULN (μmoL/L)	0.68 (0.24-1.92)	0.464
Albumin (g/L)	0.99 (0.95-1.03)	0.707
ALT1 (IU/L)
< 2 ULN	Reference	Reference	Reference	Reference
2-5 ULN	2.16 (1.31-3.56)	0.003	1.00 (0.52-1.93)	0.996
≥ 5 ULN	4.93 (2.66-9.12)	< 0.001	1.11 (0.44-2.76)	0.996
AST1 ≥ 2 ULN (IU/L)	4.42 (2.73-7.16)	< 0.001	2.05 (0.97-4.34)	0.059
PLT (109/L)	1.00 (0.99-1.01)	0.580
HBsAg (Log IU/mL)	1.13 (0.91-1.40)	0.258
HBeAg positive	1.05 (0.70-1.58)	0.818
HBV-DNA (Log IU/mL)	1.02 (0.93-1.12)	0.636
PT (s)	1.09 (0.89-1.34)	0.408
AFP (ng/mL)	1.00 (0.99-1.01)	0.622
Inflammation activity2
A < 2	Reference	Reference	Reference	Reference
A ≥ 2	5.01 (3.24-7.74)	< 0.001	3.53 (2.11-5.92)	< 0.001

¹Normal alanine aminotransferase and aspartate aminotransferase levels are 40 U/L for women and men.

²Inflammation activity was calculated as a range of 0-3 according to the METAVIR system. BMI: Body mass index; TBIL: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelet count; HBV: Hepatitis B virus; PT: Prothrombin time; AFP: Alpha fetoprotein; ULN: Upper limit of normal; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B envelope antigen.