Effect of liver inflammation on accuracy of FibroScan device in assessing liver fibrosis stage in patients with chronic hepatitis B virus infection

Table 2 Accuracy of liver stiffness measurement values by transient elastography in diagnosing ≥ F2, ≥ F3, and F4, as measured by area under the receiver operating characteristic curve (n = 416)

Fibrosis stage	AUC (95%CI)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Cut-off point
≥ F2	0.863 (0.826-0.895)	83.40	81.71	86.01	78.49	≥ 7.3
≥ F3	0.911 (0.880-0.937)	80.74	87.19	76.59	89.72	≥ 9.7
F4	0.918 (0.887-0.942)	86.76	89.08	61.47	97.10	≥ 11.3

AUC: Area under the receiver operating characteristic curve; NPV: Negative predictive value; PPV: Positive predictive value; ≥ F2: Significant fibrosis; ≥ F3: Advanced fibrosis; F4: Cirrhosis.