Clinicopathological features and prognostic factors associated with gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasms in Chinese patients

Table 4 Comparative of mixed neuroendocrine-non-neuroendocrine neoplasms, neuroendocrine tumors, and neuroendocrine carcinomas

Variable	NET (n = 55)	NEC (n = 47)	MiNEN (n = 46)	P value
				NET vs MiNEN	NEC vs MiNEN
Male/female	24/31	34/13	34/12	0.004	0.864
Age [yr, mean (range)]	49 (11-85)	64 (40-83)	65 (41-84)	< 0.001	0.857
Location				< 0.001	0.162
Stomach	7	26	35
Intestine	39	15	9
Pancreas	9	6	2
Size [cm, mean (range)]	1.7 (0.2-11)	5.2 (1.5-16.0)	5.4 (0.5-18)	< 0.001	0.742
Ki-67 index				< 0.001	0.051
< 2%	15	2	0
2%-20%	39	5	1
> 20%	1	40	45
Lymph node				< 0.001	0.691
metastasis
Presence	13	33	34
Absence	42	14	12
Distant metastasis				< 0.001	0.156
Presence	2	21	14
Absence	53	26	32
Survival time				< 0.001	0.001
(mo)
Median	50	14	30
Mean	49.3	34	28.6
Follow-up				< 0.001	0.054
Dead	3	34	27
Alive	44	7	15

MiNEN: Mixed neuroendocrine-non-neuroendocrine neoplasms; NET: Neuroendocrine tumors; NEC: Neuroendocrine carcinomas.