Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis

Figure 7 CircVAPA promotes tumor growth of chemoresistant gastric cancer cells in vivo. A-D: The impact of circVAPA on tumor growth of melanoma cells in vivo was analyzed by nude mice tumorigenicity assay (n = 5). SGC7901/cisplatin cells were treated with control shRNA or circVAPA shRNA. Representative images of dissected tumors from nude mice are shown (A). The average tumor volume (B) and weight (C) were calculated and presented. The expression of miR-125b-5p was measured by qPCR in the tumor tissues of the mice (D); E: The expression of STAT3 was tested by Western blot analysis in the tumor tissues of the mice. Data are presented as the mean ± SD. ^bP < 0.01.