Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells

Figure 5 Membrane palmitoylated protein is the target of miR-34a. A: MicroRNA 34a (miR-34a) and membrane palmitoylated protein (MPP2) mRNA had binding sites; B and C: Effect of miR-34a expression change on MPP2 compared with the negative control (NC) demethylation group, a indicates ^aP < 0.05; D: miR-34a had a positive correlation with MPP2 mRNA, ^aP < 0.05, ^cP < 0.001; and E: Double luciferase reporter gene verified the targeting relationship of miR-34a/MPP2; compared with NC mimics, a indicates ^aP < 0.05.