Demethylation of miR-34a upregulates expression of membrane palmitoylated proteins and promotes the apoptosis of liver cancer cells

Figure 4 Membrane palmitoylated proteins promote cell apoptosis and inhibits cell proliferation, invasion, and migration. A: Overexpression of membrane palmitoylated proteins (MPP2) did not affect methylation and the expression level of microRNA 34a (miR-34a); B: MPP2 inhibited cell migration; compared with the negative control-short hairpin (NC-sh) group, a indicates ^aP < 0.05, ^bP < 0.01, ^cP < 0.001; C: MPP2 inhibited cell invasion, compared with the NC-sh group, b indicates ^bP < 0.01; D: MPP2 inhibited cell activity compared with the NC-sh group, a indicates ^aP < 0.05; and E: MPP2 inhibited the downregulation of B-cell lymphoma 2 (Bcl-2), N-cadherin and β-catenin expression, but promoted caspase 9, caspase 3, E-cadherin, Bcl-2-associated X protein compared with the NC-sh group, a indicates ^aP < 0.05).