Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease

Table 2 Symptom scores and remission time before and after treatment in the two groups

Group	PPI (n = 12)	WMT (n = 15)	P value1
Pre-GERDQ (median; IQR)	12 (9, 13.75)	12 (10, 12)	0.746
Post-GERDQ (median; IQR)	11 (8.25, 13.5)	7 (7, 8)	0.004
Intra-group, P value2	0.477	0.003
Pre-RDQ (median, IQR)	26 (18, 33)	23 (16, 25)	0.203
Post-RDQ (median, IQR)	20.5 (12.75, 26)	8 (6, 12)	0.003
Intra-group, P value	0.005	0.002
Remission time (median, IQR; mo)	2 (0, 4)	8 (3, 17)	0.002

¹The RDQ and GERDQ scores between two groups were analyzed by non-parametric Mann-Whitney test.

²The intra-group RDQ and GERDQ scores were analyzed by non-parametric Wilcoxon signed-rank test.

WMT: Washed microbiota transplantation; PPI: Proton pump inhibitors; RDQ: Reflux disease questionnaire; GERDQ: Gastroesophageal reflux disease questionnaire; IQR: Interquartile range.