Histopathology and the predominantly progressive, indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy

Table 2 Clinical and pathological parameters of hepatitis C virus patients by pretreatment and posttreatment predominantly progressive, indeterminate and predominately regressive score (n = 23)

Parameters	Progressive	Indeterminate	Regressive	P value
Pretreatment, n (%)	15 (65)	7 (30)	1 (4)
Age (yr)	50.3 ± 12.3	43.9 ± 12.5	27.0	0.154
Males, n (%)	6 (40)	3 (43)	0 (0)	0.709
ALT (U/L)	66 (57)	48 (38)	50 (0)	0.469
TBil (μmol/L)	14.0 (8.0)	12.0 (6.0)	9.0 (0.0)	0.642
Albumin (g/L)	44.0 ± 3.9	47.0 ± 3.1	45.0	0.233
Platelets (× 103 μL)	129.3 ± 60.2	188.0 ± 51.5	268.0	0.024
INR	1.04 (0.16)	1.00 (0.2)	1.00 (0.00)	0.307
HCV RNA (log IU/L)	6.01 ± 0.66	6.46 ± 0.90	6.60	0.375
LSM, kPa	8.8 (14.8)	6.6 (2.9)	6.6 (0.0)	0.331
HAI score, n (%)				0.070
0-3	0 (1)	1 (14)	0 (0)
4-6	1 (7)	2 (29)	1 (100)
7-9	4 (27)	3 (43)	0 (0)
≥ 10	10 (67)	1 (14)	0 (0)
Ishak score, n (%)				0.072
3-4	4 (27)	5 (71)	1 (100)
5-6	11 (73)	2 (29)	0 (0)
Posttreatment, n (%)	5 (22)	9 (39)	9 (39)
Age (yr)	50.4 ± 12.0	47.8±14.1	45.4 ± 13.4	0.802
Males, n (%)	1 (20)	3 (33)	5 (56)	0.384
ALT (U/L)	25 (21)	17 (8)	15 (15.5)	0.340
TBil (μmol/L)	19 (10)	10 (6)	14 (9)	0.149
Albumin (g/L)	44.0 ± 4.2	44.9 ± 1.9	46.0 ± 1.8	0.353
Platelets (× 103 μL)	156.4 ± 63.3	184.4 ± 80.3	151.1 ± 65.8	0.552
INR	1.13 (0.15)	1.00 (0.14)	1.09 (0.15)	0.052
LSM, kPa	11.5 (22.8)	7.8 (7.4)	6.8 (5.2)	0.683
HAI score, n (%)				0.338
0-3	1 (20)	4 (44)	6 (67)
4-6	2 (40)	4 (44)	3 (33)
7-9	1 (20)	0 (0)	0 (0)
≥ 10	1 (20)	1 (11)	0 (0)
Ishak score, n (%)				0.339
3-4	2 (40)	6 (67)	6 (67)
5-6	3 (60)	3 (33)	3 (33)

ALT: Alanine aminotransferase; TBil: Total bilirubin; INR: International normalized ratio; HCV: Hepatitis C virus; LSM: Liver stiffness measurement; HAI: Histology activity index.