Combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in mid- and long-term prediction of hepatocellular carcinoma among cirrhotic patients

Figure 1 Receiver operating characteristic curves of the combination of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein as compared to squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in predicting two-year mortality in the estimation cohort. The clinical relevance of squamous cell carcinoma antigen immunocomplex and alpha-fetoprotein in patients with cirrhosis was determined by the calculation of the area under the receiver operating characteristic. Baseline serum levels distribution above the cut-off of the two biomarkers in patients who developed hepatocellular carcinoma vs patients who did not was compared. AUROC, area under the receiver operating characteristic. Comparison of the AUROCs estimated for each set. AFP: Alpha-fetoprotein; SCCA-IgM: Squamous cell carcinoma antigen immunocomplex.