Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma

doi:10.3748/wjg.v27.i48.8302

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Dec 28, 2021 (publication date) through Dec 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2021; 27(48): 8302-8322
Published online Dec 28, 2021. doi: 10.3748/wjg.v27.i48.8302

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Figure 8 Hepatitis B core antigen promoted tumor anti-apoptosis, proliferation and chemoresistance in hepatocellular carcinoma cells by the miR-135a-5p/vesicle-associated membrane protein 2 axis. HBV: Hepatitis B virus; HBc: Hepatitis B core antigen; Bcl-2: B-cell lymphoma-2; MCM2: Mini-chromosome maintenance protein-2; PCNA: Proliferating cell nuclear antigen; VAMP2: Vesicle-associated membrane protein 2; Dox: Doxorubicin hydrochloride; MVB: Multivesicular body; ER: Endoplasmic reticulum.

Citation: Wei XC, Xia YR, Zhou P, Xue X, Ding S, Liu LJ, Zhu F. Hepatitis B core antigen modulates exosomal miR-135a to target vesicle-associated membrane protein 2 promoting chemoresistance in hepatocellular carcinoma. World J Gastroenterol 2021; 27(48): 8302-8322
URL: https://www.wjgnet.com/1007-9327/full/v27/i48/8302.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i48.8302