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Copyright ©The Author(s) 2021.
World J Gastroenterol. Dec 28, 2021; 27(48): 8201-8215
Published online Dec 28, 2021. doi: 10.3748/wjg.v27.i48.8201
Figure 1
Figure 1 Protein S-palmitoylation. A: The ZDHHC-type palmitoyltransferases are integral membrane proteins with at least four transmembrane helices. The cysteine rich domain containing the DHHC motif is between the second and third transmembrane helices; B: Scheme showing the palmitoylation and depalmitoylation process. ZDHHC are self-palmitoylated first before transferring the palmitoyl group to substrate proteins. Depalmitoylation is catalyzed by the alpha/beta hydrolases.