Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor

Table 3 Specific distribution of the P2X7 receptor in relation to cells with different chemical code that integrate the enteric nervous system

Ref.	Species	Tissue	Chemical cellular code (p2x7 receptor expression, %)
			Submucosal plexus	Myenteric plexus
Hu et al[125]	Guinea pig	Ileum	ChAT, calret, NPY and SP	nNos, calret, calb, NPY, SP, and HuC/D
Hu et al[125]	Guinea pig	Stomach and intestines	N/A	nNos, calret, calb, NPY, SP, and HuC/D
Vanderwinden et al[126]	Rat	Stomach, jejunum, and colon	S100β	S100β
Gulbransen et al[19]	Human and mice	Colon	+	+
Girotti et al[121]	Rat	Large intestine	P2X7 in 100% of ChAT, calret, and calb; ChAT (22.5%), calret (35%) and calb (12.7%)	P2X7 in 100% of ChAT, nNOS, calret, and calb; ChAT (12.7%), nNOS (35.7%), calret (17.6%) and calb (8.3%)
Palombit et al[127]	Rat	Ileum	N/A	P2X7 in 100% of ChAT, nNOS, calret, and calb; ChAT (42.2%), nNOS (24.5%), calret (33.5%), and calb (10.7%)
Antonioli et al[128]	Rat	Distal colon	N/A	P2X7 in 100% of HuC/D
Da Silva et al[129]	Rat	Distal colon	N/A	P2X7 in 100% of ChAT, nNOS, calret, calb, and S100β
Da Silva et al[130]	Rat	Distal colon	P2X7 in 100% of calret, calb, HuC/D, and S100β	N/A

(+): P2X7 receptor positivity without cellular chemical code information; N/A: Not applicable; ir: Immunoreactive; ChAT: Acetylcholine transferase enzyme-ir; nNOS: Neuronal nitric oxide synthase enzyme-ir; Calret: Calretinin-ir; Calb: Calbindin-ir; NPY: Neuropeptide Y-ir; SP: Substance P-ir; HuC/D: Neuronal pan-ir; NF200: Neurofilament 200-ir; GFAP: Glial fibrillary acid protein-ir; S100β: Protein β for calcium S100-ir labeling.