Multimodality management of gallbladder cancer can lead to a better outcome: Experience from a tertiary care oncology centre in North India

Table 2 Association between patient and disease characteristics with outcomes

	Overall survival			Disease free survival
Factor	HR	95%CI	P value	HR	95%CI	P value
Sex
Female	0.92	[0.56-1.51]	0.76	0.98	[0.61-1.6]	0.96
Male
Jaundice
Yes	0.9	[0.37-2.16]	0.81	1.19	[0.48-2.93]	0.67
No
Incidental
Yes	0.24	[0.07-0.81]	0.001	0.54	[0.34-0.86]	0.01
No
Neoadjuvant therapy
Yes	2.2	[1.27-3.81]	< 0.001	2.91	[1.64-5.16]	< 0.001
No
Resection
R+	4.08	[1.22-13.64]	< 0.001	4.13	[1.22-13.9]	< 0.001
R0
Lymph node status
Positive	1.91	[1.13-3.25]	0.006	2.44	[1.4-4.17]	0.001
Negative
T stage
T1a-T2
T3-T4	5.01	[3.06-8.18]	< 0.001	4.21	[2.55-6.94]	< 0.001
LVI
Yes	2.08	[1.22-3.5]	0.001	2.12	[1.23-3.64]	0.001
No
PNI
Yes	3.06	[1.75-5.37]	< 0.001	2.54	[1.45-4.45]	< 0.001
No
Poorly differentiated
Yes
No	1.75	[0.81-3.7]	0.07	1.43	[0.66-3.08]	0.28

HR: Hazard ratio; CI: Confidence interval; LVI: Lymphovascular invasion; PNI: Perineural invasion.