MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers

doi:10.3748/wjg.v27.i45.7801

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastroenterol. Dec 7, 2021; 27(45): 7801-7812
Published online Dec 7, 2021. doi: 10.3748/wjg.v27.i45.7801

Table 2 Gene enrichment analysis of decreased microRNAs in ulcerative colitis patients compared with Crohn’s disease patients

Pathway	P value	FDR
Proteoglycans in cancer	2.27E-11	6.99E-09
FoxO signaling pathway	2.37E-11	3.64E-09
Pathways in cancer	7.49E-11	7.69E-09
Colorectal cancer	1.25E-07	5.51E-06
TGF-β signaling pathway	1.47E-07	4.53E-06
Signaling pathways regulating pluripotency of stem cells	4.72E-07	1.32E-05
Autophagy	5.58E-07	1.32E-05
ErbB signaling pathway	9.95E-07	2.19E-05
mTOR signaling pathway	3.70E-06	7.61E-05
MAPK signaling pathway	1.66E-05	2.22E-04

FoxO: Forkhead box protein O; TGF: Transforming growth factor-β; ErbB: Erythroblastic leukemia viral oncogene homolog; mTOR: Mammalian target of rapamycin; MAPK: Mitogen-activated protein kinase; FDR: False discovery rate-adjusted.

Citation: Quaglio AEV, Santaella FJ, Rodrigues MAM, Sassaki LY, Di Stasi LC. MicroRNAs expression influence in ulcerative colitis and Crohn's disease: A pilot study for the identification of diagnostic biomarkers. World J Gastroenterol 2021; 27(45): 7801-7812
URL: https://www.wjgnet.com/1007-9327/full/v27/i45/7801.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i45.7801