Copyright
©The Author(s) 2021.
World J Gastroenterol. Nov 28, 2021; 27(44): 7582-7596
Published online Nov 28, 2021. doi: 10.3748/wjg.v27.i44.7582
Published online Nov 28, 2021. doi: 10.3748/wjg.v27.i44.7582
Figure 2 Main signaling pathways activated by orexins/orexins receptors system involved in peripheral diseases.
PLC: Phospholipase C; cAMP: Cyclic adenosine monophosphate; CREB: C-AMP response element-binding protein; PI3K: Phosphoinositide 3-kinase; Akt: Protein kinase B; MAPK: Mitogen-activated protein kinase; ERK1/2: Extracellular signal-regulated kinase 1 and 2; P38: Mitogen-activated protein kinase; SHP2: Src homology 2 domains of Src homology 2-containing phosphatase 2.
- Citation: Couvineau A, Voisin T, Nicole P, Gratio V, Blais A. Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions. World J Gastroenterol 2021; 27(44): 7582-7596
- URL: https://www.wjgnet.com/1007-9327/full/v27/i44/7582.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i44.7582