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Copyright ©The Author(s) 2021.
World J Gastroenterol. Nov 28, 2021; 27(44): 7649-7660
Published online Nov 28, 2021. doi: 10.3748/wjg.v27.i44.7649
Table 3 Immunohistochemical markers for the diagnosis of intestinal neuronal dysplasia type B
Immunohistochemical marker
Immunoexpression pattern
Bcl-2[54]Positive expression in immature and mature ganglion cells
Calretinin[39,54]Positive expression in mature ganglion cells in submucosal and myenteric plexuses
Positive expression in intrinsic nerve fibers and ectopic neurons in the mucosa
c-kit[60-62]Positive expression in Cajal cells in muscle layers and myenteric nerve plexuses
GAP43[63]Absence of expression in muscularis mucosae and/or in the circular muscular and/or longitudinal muscular
Positive expression in nerve plexuses
Hu C/D[38]Positive expression in mature ganglion cells in submucosal and myenteric plexuses
NGF (mast cells)[64]Expression of mast cells close to ganglia
NCAM (CD56)[60,61,63,65]Positive expression in neurons of the muscular layers
Variable expression in nerve fibers in muscle layers and mucosa
NO synthase[66]Positive expression in ganglion cells
NSE[61]Positive expression in nerve fibers in the muscle layers and mucosa
Peripherin[66,67]Positive expression in ganglion cells
PGP9.5[60,68]Positive expression in enlarged nerve trunks, hyperplastic nerve ganglia, and heterotopic nerve cells
Positive expression in neurons of the inner intestinal muscle layer
PTEN[69]Reduced expression in submucosal and myenteric nerve plexuses
RET[54,66]Positive expression in mature and immature ganglion cells
S100[60,61,66]Positive expression in ganglion cells
Positive expression in nerve fibers in the muscular layers and mucosa
Synaptophysin[60,62,63,65,66,70]Positive expression in synaptic vesicles in plexuses and nerve fibers
SMA (1a4)[61,71]Positive expression in muscle fibers from muscular layers and muscularis mucosa
Sox10[46]Positive expression in glial and ganglion cells in nerve plexuses