Challenges in the diagnosis of intestinal neuronal dysplasia type B: A look beyond the number of ganglion cells

Table 1 Comparison between Hirschsprung’s disease and intestinal neuronal dysplasia type B regarding the main clinical and histopathological aspects

	HD	IND-B
Histopathological findings on rectal biopsies	Absence of ganglion cells in the submucosal and myenteric plexuses	Hyperplasia of the submucosal nerve plexuses
Clinical Picture	Neonatal bowel obstruction or severe constipation	Neonatal bowel obstruction or severe constipation
Treatment	Surgical (colorectal pull-through)	Diet, laxatives, enemas or surgical (if complications)

HD: Hirschsprung’s disease; IND-B: Intestinal neuronal dysplasia type B.