Survivin-positive circulating tumor cells as a marker for metastasis of hepatocellular carcinoma

Figure 4 Effect of survivin silencing and overexpression on apoptosis ability of HepG2 cells. A: Western blot analysis confirming survivin protein knockdown and upregulation in the selected clones (siRNA, siRNA-survivin, Lenti, and Lenti-survivin) and controls; B: Cell apoptosis was detected by flow cytometric analysis (n = 3). The apoptosis rate was significantly lower in the survivin-overexpressing cells (^bP < 0.01).