Liver injury changes the biological characters of serum small extracellular vesicles and reprograms hepatic macrophages in mice

Figure 6 Differentially expressed circulating microRNAs in human liver disease and common microRNAs in mice. A: Flow chart of study selection and microRNA (miRNA) screening; B: Heatmap for the expression of high-frequency human liver disease (HLD)-related circulating miRNAs in acute liver injury (ALI) and chronic liver injury (CLI) serum small extracellular vesicles (sEVs); C: Common miRNAs in the serum sEVs from mice with ALI and CLI and in the circulation in the context of HLDs. Red font: Upregulated miRNAs; Green font: Downregulated miRNAs; HC: Healthy control; AC: Acute liver injury control; CC: Chronic liver injury control; WoS: Web of Science; D: Day; W: Week.