Liver injury changes the biological characters of serum small extracellular vesicles and reprograms hepatic macrophages in mice

Figure 3 Annotations of small RNA in serum small extracellular vesicles from acute liver injury and chronic liver injury mice. A: Total RNA in serum small extracellular vesicles (sEVs) compared with the 2D group, ^cP < 0.001; B: Small RNA (sRNA) concentrations in serum sEVs compared with the 2 d group, ^cP < 0.001; C: Representative pie charts depicting the annotated sRNA species and their proportions in the different groups; D: Statistical analysis of sRNA species in sEVs. Compared with the 2 d group, ^dP < 0.0001; compared with the 8 wk group, ^fP < 0.01, ^gP < 0.0001. D: Day; W: Week; AC: Acute liver injury control; CC: Chronic liver injury control; ALI: Acute liver injury; CLI: Chronic liver injury; miRNA: MicroRNA; snoRNA: Small nucleolar RNA.