Copyright
©The Author(s) 2021.
World J Gastroenterol. Nov 21, 2021; 27(43): 7446-7461
Published online Nov 21, 2021. doi: 10.3748/wjg.v27.i43.7446
Published online Nov 21, 2021. doi: 10.3748/wjg.v27.i43.7446
Table 1 Microbiota changes in different studies regarding hepatic B and C virus
Changes of gut microbiota in patients vs healthy subjects | Ref. | |
Type of HBV infection | ||
Chronic HBV infection | ↓ Bacteroidetes and Firmicutes; ↑ Proteobacteria and Actinobacteria | Chen et al[117] |
↑ Bifidobacterium dentium; ↓ Bifidobacterium catenulatum and longum | Xu et al[118] | |
↑ Veillonellaceae; ↓ Lachnospiraceae, Rikenellaceae, Ruminococcaceae | Wang et al[119] | |
HBV liver cirrhosis | ↓↓↓ Bacteroidetes and Firmicutes; ↑↑↑ Proteobacteria and Actinobacteria | Chen et al[117] |
Decompensated HBV cirrhosis | ↓ Bifidobacteria/Enterobacteriaceae ratio; ↑ Enterobacteriaceae; ↓ Firmicutes (F.prausnitzii, Clostridium clusters XI and XIVab, Bifidobacterium); ↓ Bacteroidetes | Lu et al[120] |
HBV related hepatocellular carcinoma | ↓ Proteobacteria; ↑ Prevotella, Phascolarctobacterium, Anaerotruncus; ↑ Proteus, Veillonella, Prevotella 2, Barnesiella and Ruminococcaceae spp. | Liu et al[121] |
Type of HCV infection | ||
Chronic HCV infection without cirrhosis | ↑ Veillonella spp., Lactobacillus spp., Streptococcus spp. and Alloprevotella spp.; ↓ Bilophila spp., Clostridium IV spp., Clostridium XlVb spp., Mitsuokella spp. and Vampirovibrio spp.; No changes: Akkermansia spp., Bifidobacterium spp., Escherichia/Shigella spp., Haemophilus spp., Micrococcus spp. and Weissella spp. | Heidrich et al[122] |
Chronic HCV infection with cirrhosis | ↑↑↑ Veillonella spp., Lactobacillus spp., Streptococcus spp. and Alloprevotella spp.; ↓↓↓ Bilophila spp., Clostridium IV spp., Clostridium XlVb spp., Mitsuokella spp. and Vampirovibrio spp.; ↑↑↑ Akkermansia spp., Bifidobacterium spp., Escherichia/Shigella spp., Haemophilus spp., Micrococcus spp. and Weissella spp. | Heidrich et al[122] |
Stage 4 HCV infection (cirrhosis) | ↓ Firmicutes; ↑ Prevotella, Faecalibacterium (F. prausnitzii); ↑ Acinetobacter; ↑ Veillonella | Aly et al[123] |
- Citation: Neag MA, Mitre AO, Catinean A, Buzoianu AD. Overview of the microbiota in the gut-liver axis in viral B and C hepatitis. World J Gastroenterol 2021; 27(43): 7446-7461
- URL: https://www.wjgnet.com/1007-9327/full/v27/i43/7446.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i43.7446