Detailing the ultrastructure’s increase of prion protein in pancreatic adenocarcinoma

Figure 5 Prion protein immuno-gold particles count. A: Prion protein immuno-gold particles count in whole cells (controls vs pancreatic ductal adenocarcinoma); B: Prion protein immuno-gold particles count in cytosol (controls vs pancreatic ductal adenocarcinoma); C and D: Prion protein immuno-gold particles count in nuclear compartment. A significative difference in prion protein (PrPc) immunogold particles is observed between pancreatic ductal adenocarcinoma (PDAC) and control tissues (C); Even when analyzing the location only in PDAC cells, the nuclear compartment has a significantly higher PrPc concentration (D). ^aP < 0.0001. Comparisons between two groups were made by using Student t-test. Values are given as the mean ± SD.