Circulating tumor DNA dynamics analysis in a xenograft mouse model with esophageal squamous cell carcinoma

Figure 5 The dynamics of circulating tumor DNA in resection experiments. A: Tumor resection was performed when tumor diameter xenograft mice exceeded 10 mm, at week 7 in two-site xenograft mice, or at week 5 in four-site xenograft mice. Human telomerase reverse transcriptase (hTERT) circulating tumor DNA (ctDNA) was detected at resection (control), had decreased by 6 h, and was undetectable 1 d and 3 d after resection; B: On the other hand, in four-site xenograft mice, hTERT (ctDNA) was detected at resection (control), 6 h, 1 d, and 3 d after resection. cfDNA: Cell-free DNA.