Role of cell-free network communication in alcohol-associated disorders and liver metastasis

Figure 4 Model of extracellular vesicle interactions along the gut/liver/lung/brain axis during alcohol disorders and cancer progression. Alcohol exposure leads to enhanced gut microbiome dysbiosis, the development of alcohol-associated liver disease, lung inflammation, and neurological manifestations. The potential role of tumor- and alcohol-derived extracellular vesicles (EVs) in advanced malignancies is a potential consequence of EV organ-organ communication during alcohol disorders. BBB: Blood brain barrier; CRC: Colorectal cancer; AALD: Alcohol-associated liver disease.