Copyright
©The Author(s) 2021.
World J Gastroenterol. Nov 7, 2021; 27(41): 7190-7206
Published online Nov 7, 2021. doi: 10.3748/wjg.v27.i41.7190
Published online Nov 7, 2021. doi: 10.3748/wjg.v27.i41.7190
Table 5 Clinical characteristics of patients with non-small cell lung carcinoma and malignant melanoma who developed gastrointestinal-immune-related adverse event
Characteristic | NSCLC, n = 12 | MM, n = 13 |
Age, yr | 67 ± 11 | 67 ± 12 |
Sex, n | ||
Male | 10 | 9 |
Female | 2 | 4 |
BMI, kg/m2 | 22.2 ± 3.7 | 22.1 ± 4.4 |
ECOG PS, n | ||
0-1 | 12 | 13 |
2-3 | 0 | 0 |
Stage, n | ||
III | 1 | 2 |
IV | 11 | 11 |
Latest ICI, n | ||
Nivolumab | 2 | 5 |
Pembrolizumab | 8 | 3 |
Atezolizumab | 2 | 0 |
Ipilimumab | 0 | 5 |
Nivolumab + ipilimumab | 0 | 0 |
Diarrhea frequency | 4.3 ± 1.8 | 5.5 ± 2.5 |
CTCAE Grade, n | ||
1 | 4 | 3 |
2 | 7 | 8 |
3 | 1 | 2 |
Median ICI duration before GI-irAE onset (d), median (range) | 60 (7-567) | 75 (24-733) |
Treatment with ICIs after the onset of GI-irAEs | ||
Continued or resumed | 8 | 10 |
Discontinued | 4 | 3 |
- Citation: Yamada K, Sawada T, Nakamura M, Yamamura T, Maeda K, Ishikawa E, Iida T, Mizutani Y, Kakushima N, Ishikawa T, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M, Furune S, Hase T, Yokota K, Maeda O, Hashimoto N, Akiyama M, Ando Y, Fujishiro M. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival. World J Gastroenterol 2021; 27(41): 7190-7206
- URL: https://www.wjgnet.com/1007-9327/full/v27/i41/7190.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i41.7190