Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?

doi:10.3748/wjg.v27.i41.7144

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Nov 7, 2021 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2021; 27(41): 7144-7158
Published online Nov 7, 2021. doi: 10.3748/wjg.v27.i41.7144

Table 1 Clinical and viral characteristics of chronic hepatitis B patients enrolled in the study

	Total, n = 13
Age, yr, median (IQR)	41.35 (31.7-47.2)
Male, n (%)	11 (84.6)
Genotype, n (%)
A	3 (23.1)
C	3 (23.1)
D	2 (15.4)
E	2 (15.4)
F	3 (23.1)
ALT, IU/L, median (IQR)	124 (66-160)
HBeAg +ve, n (%)	11 (84.6)
HBV DNA, Log₁₀IU/mL, median (IQR)	8 (8-8.43)
HBV RNA, Log₁₀ copies/mL, median (IQR)	5.18 (4.94-6.02)
Fibrosis, n (%)¹
Nonsignificant	8 (61.64)
Significant	3 (23.08)
Cirrhosis, n (%)	2 (15.39)

¹Nonsignificant fibrosis indicates Ishak fibrosis stage < 3, significant fibrosis F ≥ 3 and < 5, and cirrhosis F5-6. Nonsignificant fibrosis by noninvasive markers indicates liver stiffness < 7-8.5 kPa, significant fibrosis > 7-8.5 and < 11-14 kPa and cirrhosis > 11-14 kPa by transient elastography according to World Health Organization Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection criteria[20].

F: Fibrosis; IQR: Interquartile range; ALT: Alanine aminotransferase; HBeAg +ve: Hepatitis B e-antigen positive; HBsAg: Hepatitis B virus surface antigen; HBV: Hepatitis B virus.

Citation: Garcia-Garcia S, Cortese MF, Tabernero D, Gregori J, Vila M, Pacín B, Quer J, Casillas R, Castillo-Ribelles L, Ferrer-Costa R, Rando-Segura A, Trejo-Zahínos J, Pumarola T, Casis E, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frías F. Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies? World J Gastroenterol 2021; 27(41): 7144-7158
URL: https://www.wjgnet.com/1007-9327/full/v27/i41/7144.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i41.7144