Role of cell-free network communication in alcohol-associated disorders and liver metastasis

Table 2 Extracellular vesicle components in cancer progression and metastasis

EV cargo	Type of molecule	Action on recipient cells/tissue	Type of cancer	Ref.
CEA	Protein	Inflammation	Colorectal	Yokoyama et al[162]
KRAS	Protein	Invasiveness in recipient cells	Colorectal	Beckler et al[152]
ITG	Protein	Metastatic organotropism	Breast	Hoshino et al[96]
TNC	ECM protein	Stem cell niche formation	Breast	Oskarsson et al[97]
MIF	Protein	Liver premetastatic niche formation	Pancreatic	Costa-Silva et al[168]
ZFAS1	lncRNA	Cancer growth/metastasis	Gastric	Pan et al[119]
Amino acids, lipids, TCA-cycle intermediates	Metabolites	Cancer growth	Prostate	Zhao et al[132]

CEA: Carcinoembryonic antigen; KRAS: Kirsten rat sarcoma viral oncogene; ITG: Integrins; TNC: Tenascin C; MIF: Macrophage migration inhibitory factor; ZFAS1: ZNFX1 antisense RNA1; LncRNA: Long non-coding RNA; ECM: Extracellular matrix.