Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study

Table 4 Laboratory characteristics according to the degree of alanine transaminase elevation, n (%)

Variable	ALT levels					P value
	Normal318 (74.0)	1-2 UNL73 (17.0)	2-3 UNL23 (5.3)	> 3UNL16 (3.7)	Total
Hemoglobin (gm/L) median (IQR)	12.75 (11.78:14.00)	13.00 (12.10:14.45)	13.30 (12.30:14.80)	13.35 (10.63:14.98)	12.60 (12.00:13.90)	0.09
white blood cell count (× 109)	5.00 (4.00:7.40)	6.30 (4.70:10.55)	6.30 (4.20:9.80)	7.55 (3.88:9.33)	5.00 (4.40:7.60)	0.003
Neutrophils absolute count	2.70 (1.60:4.69)	4.00 (2.40:7.73)	2.70 (1.80:7.10)	5.00 (2.60:6.97)	2.95 (1.70:5.60)	0.02
Neutrophils percentage	53.00 (41.50:66.50)	57.00 (46.00:77.50)	82.60 (44.93:92.08)	66.50 (53.25:74.50)	56.50 (42.63:70.75)	0.17
Lymphocytes absolute count	1.60 (1.20:2.30)	1.60 (1.02:2.00)	1.26 (1.06:1.80)	1.07 (0.83:1.50)	1.58 (1.10:2.20)	0.04
Lymphocytes percentages	36.00 (24.23:45.00)	22.00 (15.70:43.40)	25.55 (15.05:42.38)	22.60 (13.75:33.75)	32.70 (20.15:45.00)	0.01
Neutrophils/lymphocytes ratio	2.19 (1.40:4.19)	6.07 (2.96:9.15)	6.24 (2.83:7.96)	4.14 (2.70:15.85)	3.11 (1.56:6.16)	0.002
Platelet count	220.00 (168.00:273.25)	238.00 (168.00:309.00)	219.00 (202.00:297.00)	271.00 (160.00:343.75)	208.00 (184.00:272.00)	0.11
AST	23.00 (17.00:31.00)	46.00 (34.00:60.00)	61.00 (52.00:84.00)	154.50 (109.25:236.00)	28.00 (19.00:43.00)	< 0.001
ALT	22.00 (16.00:29.25)	56.00 (48.00:63.60)	96.00 (91.00:110.00)	183.50 (144.50:228.50)	27.00 (18.00:46.00)	< 0.001
Alkaline phosphatase	88.00 (65.50:108.50)	88.00 (77.50:134.00)	86.00 (86.00:86.00)	120.00 (90.00:151.00)	89.00 (71.00:114.50)	0.19
GGT	23.00 (20.00:34.00)	39.50 (34.00:67.75)	34.00 (22.00:50.00)	77.50 (65.00:101.25)	34.00 (22.00:50.00)	0.001
Total bilirubin	0.80 (0.50:0.90)	1.10 (0.75:1.40)	0.80 (0.35: 0.88)	1.80 (1.25:2.15)	0.80 (0.60 :1.13)	0.01
Serum albumin	4.20 (3.70:4.50)	4.00 (3.83:4.45)	3.10 (2.60)	3.80 (3.50:4.10)	4.20 (3.80:4.50)	0.29
D-dimer	0.55 (0.36:1.02)	0.58 (0.40:1.27)	0.63 (0.36:1.50)	0.58 (0.40:1.48)	0.58 (0.40:1.10)	0.23
Ferritin	245.20M (122.93:540.00)	427.80 (200.00:847.00)	438.00 (86.50:922.00)	430.50 (215.73:1076.00)	300.00 (132.80:590.00)	0.009
C-reactive protein	32.00 (5.00:64.00)	32.00 (20.00:64.00)	32.00 (9.40:64.00)	55.44 (32.00:78.23)	45.00 (8.25:64.00)	0.09
Recovery	286 (90.2)	60 (83.3)	22 (95.7)	13 (81.3)	381 (89.0)	0.18
Death	31 (9.8)	12 (16.7)	1 (4.3)	3 (18.8)	47 (11.0)

AST: Aspartate transaminase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; IQR: Interquartile range; UNL: Upper limit normal.