Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study

Table 2 Laboratory characteristics according to the degree of aspartate transaminase elevation, n (%)

Variable	AST level					P value
	Normal291 (67.99)	1-2 UNL97 (22.66)	2-3 UNL19 (4.44)	> 3UNL21 (4.91)	Total
Hemoglobin (gm/L) median (IQR)	12.80 (11.80:14.00)	13.00 (12.00:14.23)	12.85 (11.23:14.05)	13.00 (10.75:15.00)	12.60 (12.00:13.90)	0.49
white blood cell count (× 109)	5.00 (3.80:7.00)	6.20 (4.88:10.68)	6.30 (4.73:9.48)	7.40 (4.35:9.85)	5.00 (4.40:7.60)	< 0.001
Neutrophils absolute count	2.58 (1.58:4.40)	3.90 (2.20:7.87)	4.60 (3.01:8.13)	6.00 (2.74:8.33)	2.95 (1.70:5.60)	< 0.001
Neutrophils percentage	53.00 (42.00:69.00)	61.50 (43.13:80.85)	55.50 (42.75:68.25)	73.00 (55.00:89.88)	56.50 (42.63:70.75)	0.25
Lymphocytes absolute count	1.63 (1.30:2.30)	1.40 (1.01:2.35)	1.50 (0.89:1.92)	1.07 (0.80:1.48)	1.58 (1.10:2.20)	< 0.001
Lymphocytes percentages	38.00 (26.00:45.90)	23.30 (14.50:37.60)	23.40 (16.85:28.90)	14.00 (8.00:28.00)	32.70 (20.15:45.00)	< 0.001
Neutrophils/lymphocytes ratio	2.16 (1.30:3.73)	6.11 (2.12:11.26)	3.66 (3.26)	5.31 (3.83:6.84)	3.11 (1.56:6.16)	0.002
Platelet Count	225.00 (173.00:283.00)	221.00 (174.50:286.50)	251.00 (180.75:319.75)	210.00 (146.50:293.50)	208.00 (184.00:272.00)	0.62
AST	22.00 (17.00:28.00)	46.00 (41.00:55.50)	85.00 (72.75:95.25)	156.00 (117.00:252.00)	28.00 (19.00:43.00)	< 0.001
ALT	22.00 (16.00:30.00)	48.00 (36.00:68.00)	68.00 (44.00:92.75)	142.00 (93.50:217.50)	27.00 (18.00:46.00)	< 0.001
Alkaline phosphatase	89.00 (68.50:112.00)	82.50 (76.50:88.50)	155.00 (125.25:349.00)	111.00 (84.00:144.00)	89.00 (71.00:114.50)	0.01
GGT	31.00 (20.00:34.00)	39.50 (31.25:62.25)	67.50 (65.00)	90.00 (65.00)	34.00 (22.00:50.00)	0.005
Total bilirubin	0.80 (0.50:1.10)	0.90 (0.70:1.13)	1.15 (0.88:1.65)	1.80 (0.75:2.15)	0.80 (0.60 :1.13)	0.09
Serum albumin	4.20 (3.80:4.50)	4.10 (3.90:4.45)	3.80 (3.80)	3.80 (2.90:4.10)	4.20 (3.80:4.50)	0.13
D-dimer	0.54 (0.35:1.02)	0.57 (0.40:1.21)	1.08 (0.55:1.50)	0.90 (0.40:2.24)	0.58 (0.40:1.10)	0.005
Ferritin	230.00 (110.00:486.00)	406.85 (200.00:773.25)	804.00 (317.50:960.50)	540.00 (231.45:1219.10)	300.00 (132.80:590.00)	< 0.001
C-reactive protein	32.00 (5.00:64.00)	43.22 (14.40:64.00)	64.00 (31.50:109.85)	39.23 (32.00:64.00)	45.00 (8.25:64.00)	0.002
Recovery	273 (93.8)	78 (81.3)	11 (61.1)	17 (81.0)	379 (89.0)	< 0.001
Death	18 (6.2)	18 (18.8)	7 (38.9)	4 (19.0)	47 (11.0)

Data are presented as median and interquartile range (IQR). AST: Aspartate transaminase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; IQR: Interquartile range.