Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system

Figure 6 Nonalcoholic fatty liver disease and hematological traits associated genes. A: Venn diagram showing the set of genes associated with liver traits (ICD10 codes: K70, K76, K74 and K75), platelet count, leukocyte count, and neutrophil count, as well as their overlapping genes in the United Kingdom Biobank. Approximately 30 million variants in the United Kingdom Biobank dataset sourced from the Neale's database (http://www.nealelab.is/uk-biobank/) were comprehensively tested for association with liver and blood cell traits, including platelet, leukocyte and neutrophil counts. B: Overlap between nonalcoholic fatty liver disease-associated genes and those associated with hematological traits. The chart shows information on previously known single nucleotide polymorphisms-trait associations reported in the genome-wide association studies (GWAS) catalog for all single nucleotide polymorphisms associated with nonalcoholic fatty liver disease in the United Kingdom Biobank GWAS database; the analysis was conducted using the FUMA GWAS tool (https://fuma.ctglab.nl/).