Pleiotropy within gene variants associated with nonalcoholic fatty liver disease and traits of the hematopoietic system

Figure 4 Gene Ontology biological processes of the top 50 genes associated with platelet count. The chart shows fold enrichment in biological processes of genes associated with platelet count with respect to those present in the whole genome. The input list of platelet count-associated variants was generated by conducting a search via the Open Target platform, which contains data retrieved from genome-wide association studies Catalog (https://www.ebi.ac.uk/gwas) and phenome-wide association studies (https://phewascatalog.org/). The whole list of genes associated with platelet count contains 305 loci, as shown in Supplementary Figure 2. Gene mapping and analysis was conducted using the FUMA genome-wide association studies tool (https://fuma.ctglab.nl/). Genes belonging to the pathways as overlapping genes are shown as a heatplot to the right.