Effect of remote ischemic preconditioning among donors and recipients following pediatric liver transplantation: A randomized clinical trial

Table 4 Subgroup analyses among four groups in recipients

Stratum	Mean difference in postoperative log maximal ALT compared with S-RIPC (95%CI)			Mean difference in postoperative log maximal AST compared with S-RIPC (95%CI)
	D-RIPC	R-RIPC	DR-RIPC	D-RIPC	R-RIPC	DR-RIPC
Gender
Male	0.03 (-0.31, 0.38)	0.11 (-0.24, 0.47)	0.11 (-0.25, 0.47)	0.11 (-0.23, 0.44)	0.20 (-0.14, 0.55)	0.15 (-0.21, 0.50)
Female	-0.06 (-0.50, 0.37)	0.21 (-0.21, 0.64)	0.32 (-0.10, 0.73)	-0.06 (-0.41, 0.29)	0.01 (-0.34, 0.35)	0.19 (-0.15, 0.53)
PELD
≤ 16	-0.03 (-0.40, 0.33)	-0.05 (-0.40, 0.31)	0.11 (-0.27, 0.48)	0.15 (-0.18, 0.47)	-0.06 (-0.38, 0.27)	0.17 (-0.16, 0.51)
> 16	0.02 (-0.40, 0.43)	0.44 (0.02, 0.86)	0.33 (-0.07, 0.73)	-0.11 (-0.46, 0.25)	0.33 (-0.03, 0.69)	0.17 (-0.17, 0.51)
Time of cold ischemia
< 60	0.28 (-0.07, 0.63)	0.29 (-0.07, 0.64)	0.29 (-0.09, 0.66)	0.25 (-0.13, 0.63)	0.27 (-0.11, 0.66)	0.24 (-0.16, 0.65)
≥ 60	-0.30 (-0.72, 0.12)	0.08 (-0.34, 0.50)	0.18 (-0.22, 0.57)	-0.19 (-0.50, 0.12)	-0.05 (-0.35, 0.26)	0.13 (-0.16, 0.42)
GRWR
2.5-4	0.08 (-0.22, 0.38)	0.25 (-0.04, 0.53)	0.28 (-0.01, 0.58)	-0.01 (-0.27, 0.25)	0.10 (-0.16, 0.35)	0.19 (-0.07, 0.46)
< 2.5 or > 4	-0.18 (-0.77, 0.40)	0.07 (-0.62, 0.75)	0.13 (-0.48, 0.74)	0.12 (-0.41, 0.64)	0.16 (-0.45, 0.77)	0.14 (-0.40, 0.68)
Kasai operation
Yes	-0.11 (-0.47, 0.24)	0.06 (-0.29, 0.42)	0.18 (-0.18, 0.54)	0.00 (-0.28, 0.29)	0.00 (-0.29, 0.29)	0.19 (-0.10, 0.48)
No	0.15 (-0.29, 0.58)	0.31 (-0.12, 0.74)	0.28 (-0.15, 0.72)	0.07 (-0.35, 0.50)	0.25 (-0.17, 0.68)	0.15 (-0.27, 0.57)

For maximum alanine transaminase and maximum aspartate aminotransferase, no significant differences were found in subgroup analyses. ALT: Alanine transaminase; AST: Aspartate aminotransferase; CI: Confidential interval; D-RIPC: Donors received remote ischemic preconditioning; DR-RIPC: Both donors and recipients received remote ischemic preconditioning; GRWR: Graft/recipient's body weight ratio; PELD: Pediatric end-stage liver disease; R-RIPC: Recipients received remote ischemic preconditioning; S-RIPC: Remote ischemic preconditioning with no intervention.