Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling

Figure 5 The mRNA expression levels of collagen type I, III, elastin and lysyl oxidase-like-2 in the colon tissues of rats in different groups. Data were presented as the mean ± SD form six independent experiments. ^aP < 0.05, control compared with 1,2-dimethylhyrazine (DMH); ^cP < 0.05, ^dP < 0.01, DMH compared with cold exposure and capsaicin-treated group; ^eP < 0.05, cold exposure compared with capsaicin-treated group. LOXL2: Lysyl oxidase-like-2.