Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling

Figure 1 Colonic morphology of rats in different groups. A and B: Changes in colon length and colonic morphology; C: Stiff colonic tissues in cold exposure group. ^aP < 0.05, control compared with 1,2-dimethylhyrazine (DMH); ^cP < 0.05, ^dP < 0.01, DMH compared with cold exposure and capsaicin-treated group; ^eP < 0.05, cold exposure compared with capsaicin-treated group.