Copyright
©The Author(s) 2021.
World J Gastroenterol. Oct 21, 2021; 27(39): 6631-6646
Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6631
Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6631
Table 4 Prediction of protein function change caused by STK11/LKB1 mutation
| No. | PolyPhen | Mutation Assessor | SIFT | |||
| Score | Prediction | Score | Prediction | Score | Prediction | |
| 6 | 1 | Probably damaging | 0.98351; 4.21 | High | 0 | Deleterious |
| 13 | 1 | Probably damaging | 0.99415; 4.555 | High | 0 | Deleterious |
| 15 | 1 | Probably damaging | 0.98178; 4.165 | High | 0 | Deleterious |
| 16 | 1 | Probably damaging | 0.98818; 4.34 | High | 0.01 | Deleterious |
| 23 | 0.022 | Benign | 0.56769; 1.78 | Low | 0.26 | Tolerated |
- Citation: Gu GL, Zhang Z, Zhang YH, Yu PF, Dong ZW, Yang HR, Yuan Y. Detection and analysis of common pathogenic germline mutations in Peutz-Jeghers syndrome. World J Gastroenterol 2021; 27(39): 6631-6646
- URL: https://www.wjgnet.com/1007-9327/full/v27/i39/6631.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i39.6631