Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities

doi:10.3748/wjg.v27.i39.6572

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2021; 27(39): 6572-6589
Published online Oct 21, 2021. doi: 10.3748/wjg.v27.i39.6572

Table 2 Landmark trails on use of neoadjuvant chemotherapy

Study	No. of patients	Treatment arms	Resection rate, %	R0	Median DFS in mo	Median OS in mo
PACT-15[44]	93 Resectable	Surgery + gemcitabine	85	27	4.7	20.4
		Surgery + 6 PEXG	90	37	12.4	26.4
		3PEXG + surgery + 3 PEXG	84	63	16.9	16.9
PREOPANC-01[48]	248 Resectable + BRPC	26Gy/15fr + gemcitabine	60	63	9.9	17.1
PREOPANC-01[48]	248 Resectable + BRPC	Surgery	72	31	7.9	13.7

BRPC: Borderline resectable pancreatic cancer; DFS: Disease-free survival; OS: Overall survival; PEXG: Cisplatin, epirubicin, gemcitabine, and capecitabine.

Citation: Manrai M, Tilak TVSVGK, Dawra S, Srivastava S, Singh A. Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities. World J Gastroenterol 2021; 27(39): 6572-6589
URL: https://www.wjgnet.com/1007-9327/full/v27/i39/6572.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i39.6572