Fecal metabolomic profiles: A comparative study of patients with colorectal cancer vs adenomatous polyps

Figure 1 Fecal water metabolite levels of colorectal cancer, polyps’ patients and healthy controls. Boxplots of fold-change (FC) values for the significantly altered metabolites. Red bars represent metabolites levels that remain significant after the false discovery rate (FDR) correction (FDR P < 0.05), green bars are the metabolites that are no more significant after the FDR correction (P < 0.05). Cliff’s delta effect size is also reported for each metabolites in the comparisons (a: Small effect, b: Medium effect, c: Large effect). A: Comparison between healthy controls (HCs) and colorectal cancer (CRC) patients, negative log₂(FC) values mean lower metabolite levels in CRC fecal samples, positive log₂(FC) values report higher content in CRC compared to HCs; B: Negative log₂(FC) represent higher metabolite levels in CRC patients compared to polyp patients; C: Comparison between HCs and polyp patient-negative log₂(FC) values mean lower metabolite levels in polyp patients fecal water.