Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer

Figure 1 Common functional properties of specificity protein transcription factors and nuclear receptor 4A1 in pancreatic and other cancer cells. Specificity protein (Sp) transcription factors (TFs) (Sp1, Sp3 and Sp4) bind GC-rich gene promoter sequences to activate gene expression associated with enhanced cell proliferation, survival, migration, invasion and metastasis. Nuclear receptor 4A1 (NR4A1) binds as monomer or homodimers to NBRE and NuRE promoter elements and NR4A1 also acts as a cofactor for Sp1 and Sp4-regulated genes and NR4A1/Sp binds GC-rich promoter sequences. Sp: Specificity protein; TFs: Transcription factors; NR4A1: Nuclear receptor 4A1.