Biomarkers for gastrointestinal adverse events related to thiopurine therapy

doi:10.3748/wjg.v27.i38.6348

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Oct 14, 2021 (publication date) through Jan 3, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2021; 27(38): 6348-6356
Published online Oct 14, 2021. doi: 10.3748/wjg.v27.i38.6348

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Figure 1 Thiopurine metabolic pathway and possible biomarkers for drug-related toxicity. Dashed arrows indicate the impact of PACSIN2 on TPMT activity and the interaction between PACSIN2 and Rac-1. AZA: Azathioprine; ITPA: Inosine triphosphate pyrophosphatase; IMPDH: Inosine-5′-monophosphate dehydrogenase; GMPS: GMP synthase; GST: Glutathione-S-transferase; Me-TIMP: Methyl-thioinosine monophosphate; Me-TITP: Methyl-thioinosinetriphosphate; MP: Mercaptopurine; MMP: Methyl-mercaptopurine; NUDT15: Nudix hydrolase 15; PACSIN2: Protein kinase C and casein kinase substrate in neurons protein 2; TGDP: Thioguanine diphosphate; TGMP: Thioguanine monophosphate; TGTP: Thioguanine triphosphate; TIMP: Thioinosine monophosphate; TITP: Thioinosine triphosphate; TNG: 6-Thioguanine nucleotide; TPMT: Thiopurine S-methyltransferase; TXMP: Thioxanthine monophosphate; 6-TU acid: Thiouric acid; XO: Xanthine oxidase.

Citation: Zudeh G, Franca R, Stocco G, Decorti G. Biomarkers for gastrointestinal adverse events related to thiopurine therapy. World J Gastroenterol 2021; 27(38): 6348-6356
URL: https://www.wjgnet.com/1007-9327/full/v27/i38/6348.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i38.6348