Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer

Table 1 Specificity protein regulated genes in pancreatic cancer cells

Functional	Sp-regulated gene
Cell proliferation and cell cycle progression	EGFR, IGFR, cyclin D1, PIK3R1, pmTOR, 4-EBP, pS6RP, STAT3, pSTAT3, NFkB-p65/950
Survival and apoptosis	Survivin, bcl-2, PARP cleavage, APAF1, ATM, TNFRSF25, COX2, NFkB-p65/5
Cell migration/movement EMT	Β1-integrin, α2-integrin, MTSS1, vimentin
Angiogenesis	VEGF, VEGFR1, VEGFR2, COX2
Other pro-oncogenic factors	TNFα, BRCA1, ARHGEF2, Ajuba, MALAT-1, RAS-6TP, FAS

A detailed analysis of specificity protein (Sp)-regulated genes (Sp1, Sp3 and Sp4) in Panc1 cells based on RNAseq after Sp knockdown has been reported[66] and reviewed[20]. Sp: Specificity protein; EMT: Epithelial-mesenchymal transition.