Increased systemic RNA oxidative damage and diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection

Figure 3 Liquid chromatography-tandem mass spectrometry measurement of 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2-deoxyguanosine in the urine of Sprague-Dawley rats. A: Urinary 8-oxo-7,8-dihydroguanosine; B: Urinary 8-oxo-7,8-dihydro-2-deoxyguanosine. n = 12 per group on day 0 and day 1; n = 9 per group on day 3 and day 5; n = 6 per group on day 9; n = 3 per group on day 13, day 15, and day 18. 0: Before infection. 1-18: The number of days after the establishment of the Shigella flexneri infection model. ^aP < 0.05. 8-oxo-Gsn: 8-oxo-7,8-dihydroguanosine; 8-oxo-dGsn: 8-oxo-7,8-dihydro-2-deoxyguanosine.