Retrospective Cohort Study
Copyright ©The Author(s) 2021.
World J Gastroenterol. Oct 7, 2021; 27(37): 6262-6276
Published online Oct 7, 2021. doi: 10.3748/wjg.v27.i37.6262
Table 5 Multivariate generalized estimating equation and area under the curve hepatitis B viral loads in a hepatocellular family cohort

Nongenetic model
Mixed model
Variable
OR (95%CI)
P value
OR (95%CI)
P value
SNP
Sex, male1.955 (1.132-3.376)0.01621.918 (1.101-3.341)1/1.911 (1.097-3.328)20.02141/0.02232
Index sex, male0.903 (0.481-1.699)0.75270.914 (0.488-1.713)1/0.912 (0.482-1.725)20.77861/0.77712
Age in yr 1.012 (0.987-1.037)0.33631.007 (0.983-1.032)1/1.008 (0.983-1.033)20.56581/0.54262
Relation to index
Parent generation4.182 (0.68-25.731)0.12284.343 (0.81-23.285)1/4.091 (0.75-22.316)20.08661/0.10362
Index generation1.7 (0.844-3.423)0.13721.851 (0.912-3.756)1/1.797 (0.894-3.611)20.08811/0.09992
Index HBsAg+2.219 (1.142-4.31)0.01871.734 (0.853-3.526)1/1.816 (0.907-3.636)20.12831/0.09182
Mother’s status
HBsAg+0.828 (0.407-1.684)0.60210.766 (0.361-1.623)1/0.763 (0.360-1.619)20.48621/0.48142
Unknown0.537 (0.275-1.045)0.06730.549 (0.272-1.107)1/0.559 (0.278-1.125)20.0941/0.10302
AUC (95%CI)0.674 (0.614-0.734)< 0.0001
Genetic model
rs4775152.246 (1.164-4.333)0.01592.242 (1.113-4.515)0.0238
rs92721051.386 (0.965-1.991)0.07751.266 (0.866-1.849)0.2232
rs77565161.385 (0.765-2.509)0.28261.379 (0.753-2.524)0.2977
AUC (95%CI)0.638 (0.579-0.698)< 0.00010.705 (0.648-0.763)< 0.0001
WGRS1.644 (1.317-2.052)< 0.00011.567 (1.250-1.965)< 0.0001
AUC (95%CI)0.632 (0.573-0.692)< 0.00010.704 (0.646-0.761)< 0.0001
IDI (95%CI)0.042 (0.019-0.065)0.0003
NRI (95%CI)0.440 (0.236-0.644)< 0.0001