Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells

Figure 7 miR-588/cylindromatosis axis modulates cisplatin-resistant gastric cancer cell growth in vivo. A-D: The nude mice were injected with SGC7901 cells treated with miR-588 inhibitor, the tumor tissues (A), tumor volume (B), and tumor weight (C) were measured, and the expression of cylindromatosis (CYLD) was detected by Western blot analysis in the tumor tissues (D); E and F: The nude mice were injected with SGC7901 cells treated with CYLD overexpressing plasmid or miR-588 inhibitor, or co-treated with miR-588 inhibitor and CYLD siRNA, and the tumor tissues (E) and tumor weight (F) were measured. Data shown are the mean ± SD (n = 5). ^bP < 0.01. CYLD: Cylindromatosis.